---
ticker: "FBT"
name: "First Trust NYSE Arca Biotechnology Index Fund"
url: "https://etf.net/etf/FBT"
grade: "B"
score: 63
graded_at: "2026-10-12"
category: "Biotech & Genomics"
category_rank: "6 of 17"
methodology: "https://etf.net/methodology"
---

# FBT: First Trust NYSE Arca Biotechnology Index Fund

Grade **B**, Score 63 of 100. Rank 6 of 17 in Biotech & Genomics.

Graded Oct 12, 2026.

## Grade pillars

| Pillar | Score | Category rank |
| --- | --- | --- |
| Cost | 25 | 13 of 17 |
| Mission | 86 | 2 of 9 |
| Risk | 75 | 2 of 17 |
| Tradability | 81 | 4 of 17 |
| Holdings | 67 | 7 of 17 |
| Durability | 78 | 3 of 17 |

## Top holdings

The fund holds 31 positions. These are the largest 30, by weight.

| # | Ticker | Name | Weight |
| --- | --- | --- | --- |
| 1 | NTRA | Natera, Inc. | 4.65% |
| 2 | ILMN | Illumina, Inc. | 4.58% |
| 3 | HALO | Halozyme Therapeutics, Inc. | 4.54% |
| 4 | CORT | Corcept Therapeutics Inc. | 4.13% |
| 5 | GMAB | Genmab A/S (ADR) | 4.00% |
| 6 | RGEN | Repligen Corporation | 3.77% |
| 7 | ONC | BeOne Medicines Ltd. (ADR) | 3.71% |
| 8 | GILD | Gilead Sciences, Inc. | 3.64% |
| 9 | NEO | NeoGenomics, Inc. | 3.63% |
| 10 | AMGN | Amgen Inc. | 3.57% |
| 11 | ADMA | ADMA Biologics, Inc. | 3.57% |
| 12 | BIIB | Biogen Inc. | 3.55% |
| 13 | REGN | Regeneron Pharmaceuticals, Inc. | 3.52% |
| 14 | BNTX | BioNTech SE (ADR) | 3.32% |
| 15 | EXEL | Exelixis, Inc. | 3.32% |
| 16 | VRTX | Vertex Pharmaceuticals Incorporated | 3.29% |
| 17 | TECH | Bio-Techne Corporation | 3.18% |
| 18 | UTHR | United Therapeutics Corporation | 3.14% |
| 19 | BRKR | Bruker Corporation | 3.07% |
| 20 | TGTX | TG Therapeutics, Inc. | 3.03% |
| 21 | INCY | Incyte Corporation | 3.03% |
| 22 | SRPT | Sarepta Therapeutics, Inc. | 2.95% |
| 23 | ARGX | argenx SE (ADR) | 2.94% |
| 24 | BMRN | BioMarin Pharmaceutical Inc. | 2.90% |
| 25 | MDGL | Madrigal Pharmaceuticals, Inc. | 2.75% |
| 26 | NBIX | Neurocrine Biosciences, Inc. | 2.52% |
| 27 | VCYT | Veracyte, Inc. | 2.49% |
| 28 | ALKS | Alkermes Plc | 2.45% |
| 29 | ALNY | Alnylam Pharmaceuticals, Inc. | 2.44% |
| 30 | AXSM | Axsome Therapeutics, Inc. | 2.25% |

Source: etf.net, https://etf.net/etf/FBT. Please cite the page URL.