---
ticker: "HELX"
name: "Franklin Genomic Advancements ETF"
url: "https://etf.net/etf/HELX"
grade: "D"
score: 38
graded_at: "2026-10-12"
category: "Biotech & Genomics"
category_rank: "14 of 17"
methodology: "https://etf.net/methodology"
---

# HELX: Franklin Genomic Advancements ETF

Grade **D**, Score 38 of 100. Rank 14 of 17 in Biotech & Genomics.

Graded Oct 12, 2026.

## Grade pillars

| Pillar | Score | Category rank |
| --- | --- | --- |
| Cost | 38 | 10 of 17 |
| Mission | Not scored | — |
| Risk | 40 | 11 of 17 |
| Tradability | 34 | 12 of 17 |
| Holdings | 48 | 11 of 17 |
| Durability | 41 | 12 of 17 |

## Top holdings

The fund holds 68 positions. These are the largest 30, by weight.

| # | Ticker | Name | Weight |
| --- | --- | --- | --- |
| 1 | NTRA | Natera Inc | 10.29% |
| 2 | GH | Guardant Health Inc | 9.48% |
| 3 | KRYS | Krystal Biotech Inc | 5.28% |
| 4 | ADPT | Adaptive Biotechnologies | 4.60% |
| 5 | TWST | Twist Bioscience Corp | 4.53% |
| 6 | LGND | Ligand Pharmaceuticals | 4.49% |
| 7 | BBIO | Bridgebio Pharma Inc | 2.87% |
| 8 | MEDP | Medpace Holdings Inc | 2.71% |
| 9 | VRTX | Vertex Pharmaceuticals In | 2.64% |
| 10 | UTHR | United Therapeutics Corp | 2.63% |
| 11 | TVTX | Travere Therapeutics Inc | 2.47% |
| 12 | LLY | Eli Lilly & Co | 2.37% |
| 13 | VYLR | Vylor Inc | 2.24% |
| 14 | GRAL | Grail Inc | 2.10% |
| 15 | REGN | Regeneron Pharmaceuticals | 2.01% |
| 16 | TEM | Tempus Ai Inc-Cl A | 1.94% |
| 17 | RGEN | Repligen Corp | 1.94% |
| 18 | CDNA | Caredx Inc | 1.70% |
| 19 | CRL | Charles River Laboratorie | 1.57% |
| 20 | NBIX | Neurocrine Biosciences In | 1.46% |
| 21 | ARGX.BR | Argenx SE | 1.35% |
| 22 | JAZZ | Jazz Pharmaceuticals PLC | 1.29% |
| 23 | TXG | 10X Genomics Inc-Class A | 1.26% |
| 24 | BNTX | Biontech Se-Adr | 1.19% |
| 25 | PTCT | Ptc Therapeutics Inc | 1.08% |
| 26 | IQV | Iqvia Holdings Inc | 1.05% |
| 27 | VCYT | Veracyte Inc | 1.03% |
| 28 | KNSA | Kiniksa Pharmaceuticals I | 1.00% |
| 29 | HNGE | Hinge Health Inc-A | 0.97% |
| 30 | STOK | Stoke Therapeutics Inc | 0.94% |

Source: etf.net, https://etf.net/etf/HELX. Please cite the page URL.