---
ticker: "PBE"
name: "Invesco Biotechnology & Genome ETF"
url: "https://etf.net/etf/PBE"
grade: "B"
score: 56
graded_at: "2026-10-12"
category: "Biotech & Genomics"
category_rank: "7 of 17"
methodology: "https://etf.net/methodology"
---

# PBE: Invesco Biotechnology & Genome ETF

Grade **B**, Score 56 of 100. Rank 7 of 17 in Biotech & Genomics.

Graded Oct 12, 2026.

## Grade pillars

| Pillar | Score | Category rank |
| --- | --- | --- |
| Cost | 19 | 14 of 17 |
| Mission | 91 | 1 of 9 |
| Risk | 67 | 6 of 17 |
| Tradability | 63 | 6 of 17 |
| Holdings | 48 | 11 of 17 |
| Durability | 78 | 3 of 17 |

## Top holdings

The fund holds 33 positions. These are the largest 30, by weight.

| # | Ticker | Name | Weight |
| --- | --- | --- | --- |
| 1 | ILMN | Illumina Inc | 6.29% |
| 2 | NTRA | Natera Inc | 6.05% |
| 3 | BIIB | Biogen Inc | 5.20% |
| 4 | GILD | Gilead Sciences Inc | 5.17% |
| 5 | AMGN | Amgen Inc | 4.77% |
| 6 | VRTX | Vertex Pharmaceuticals Inc | 4.69% |
| 7 | RPRX | Royalty Pharma PLC | 4.66% |
| 8 | REGN | Regeneron Pharmaceuticals Inc | 4.55% |
| 9 | MRNA | Moderna Inc | 3.93% |
| 10 | NVAX | Novavax Inc | 3.75% |
| 11 | UTHR | United Therapeutics Corp | 2.94% |
| 12 | EXEL | Exelixis Inc | 2.93% |
| 13 | QGEN | Qiagen NV | 2.88% |
| 14 | VCYT | Veracyte Inc | 2.85% |
| 15 | HALO | Halozyme Therapeutics Inc | 2.80% |
| 16 | TGTX | TG Therapeutics Inc | 2.77% |
| 17 | RGEN | Repligen Corp | 2.65% |
| 18 | PTGX | Protagonist Therapeutics Inc | 2.65% |
| 19 | SRPT | Sarepta Therapeutics Inc | 2.62% |
| 20 | NBIX | Neurocrine Biosciences Inc | 2.58% |
| 21 | VCEL | Vericel Corp | 2.57% |
| 22 | PTCT | PTC Therapeutics Inc | 2.44% |
| 23 | LEGN | Legend Biotech Corp | 2.42% |
| 24 | BCRX | BioCryst Pharmaceuticals Inc | 2.41% |
| 25 | INCY | Incyte Corp | 2.41% |
| 26 | ARDX | Ardelyx Inc | 2.41% |
| 27 | BMRN | BioMarin Pharmaceutical Inc | 2.30% |
| 28 | COLL | Collegium Pharmaceutical Inc | 2.23% |
| 29 | ANAB | AnaptysBio Inc | 2.18% |
| 30 | ACAD | ACADIA Pharmaceuticals Inc | 1.79% |

Source: etf.net, https://etf.net/etf/PBE. Please cite the page URL.