---
ticker: "SBIO"
name: "ALPS Medical Breakthroughs ETF"
url: "https://etf.net/etf/SBIO"
grade: "C"
score: 46
graded_at: "2026-10-12"
category: "Biotech & Genomics"
category_rank: "9 of 17"
methodology: "https://etf.net/methodology"
---

# SBIO: ALPS Medical Breakthroughs ETF

Grade **C**, Score 46 of 100. Rank 9 of 17 in Biotech & Genomics.

Graded Oct 12, 2026.

## Grade pillars

| Pillar | Score | Category rank |
| --- | --- | --- |
| Cost | 38 | 10 of 17 |
| Mission | Not scored | — |
| Risk | 29 | 14 of 17 |
| Tradability | 55 | 7 of 17 |
| Holdings | 82 | 4 of 17 |
| Durability | 55 | 9 of 17 |

## Top holdings

The fund holds 104 positions. These are the largest 30, by weight.

| # | Ticker | Name | Weight |
| --- | --- | --- | --- |
| 1 | CGON | CG oncology Inc. | 3.80% |
| 2 | ORKA | Oruka Therapeutics Inc. | 3.62% |
| 3 | MANE | VeraDermics Inc. | 3.47% |
| 4 | TVTX | Travere Therapeutics Inc. | 3.33% |
| 5 | DFTX | Definium Therapeutics Inc. | 3.21% |
| 6 | DNTH | Dianthus Therapeutics Inc. | 3.10% |
| 7 | EWTX | Edgewise Therapeutics Inc. | 2.84% |
| 8 | RLAY | Relay Therapeutics Inc. | 2.68% |
| 9 | IDYA | Ideaya Biosciences Inc. | 2.36% |
| 10 | XENE | Xenon Pharmaceuticals Inc. | 2.36% |
| 11 | AMLX | Amylyx Pharmaceuticals Inc. | 2.34% |
| 12 | ACAD | ACADIA Pharmaceuticals Inc. | 2.27% |
| 13 | TARS | Tarsus Pharmaceuticals Inc. | 2.22% |
| 14 | DNLI | Denali Therapeutics Inc. | 2.06% |
| 15 | DYN | Dyne Therapeutics Inc. | 2.02% |
| 16 | ZLAB | Zai Lab Ltd. | 1.88% |
| 17 | NAMS | Newamsterdam Pharma Co. NV | 1.73% |
| 18 | MBX | MBX Biosciences Inc. | 1.70% |
| 19 | SLS | SELLAS Life Sciences Group Inc. | 1.64% |
| 20 | IRON | Disc Medicine Inc. | 1.58% |
| 21 | CLDX | Celldex Therapeutics Inc. | 1.57% |
| 22 | IMNM | Immunome Inc. | 1.48% |
| 23 | BCRX | BioCryst Pharmaceuticals Inc. | 1.45% |
| 24 | VCEL | Vericel Corp. | 1.41% |
| 25 | VRDN | Viridian Therapeutics Inc. | 1.41% |
| 26 | VERA | Vera Therapeutics Inc. | 1.36% |
| 27 | LKFT | Lakefront Biotherapeutics NV | 1.34% |
| 28 | MLYS | Mineralys Therapeutics Inc. | 1.34% |
| 29 | PVLA | Palvella Therapeutics Inc. | 1.32% |
| 30 | XNCR | Xencor Inc. | 1.26% |

Source: etf.net, https://etf.net/etf/SBIO. Please cite the page URL.