---
ticker: "XBI"
name: "State Street SPDR S&P Biotech ETF"
url: "https://etf.net/etf/XBI"
grade: "A"
score: 81
graded_at: "2026-10-12"
category: "Biotech & Genomics"
category_rank: "1 of 17"
methodology: "https://etf.net/methodology"
---

# XBI: State Street SPDR S&P Biotech ETF

Grade **A**, Score 81 of 100. Rank 1 of 17 in Biotech & Genomics.

Graded Oct 12, 2026.

## Grade pillars

| Pillar | Score | Category rank |
| --- | --- | --- |
| Cost | 81 | 3 of 17 |
| Mission | 85 | 3 of 9 |
| Risk | 47 | 10 of 17 |
| Tradability | 100 | 1 of 17 |
| Holdings | 88 | 2 of 17 |
| Durability | 89 | 1 of 17 |

## Top holdings

The fund holds 165 positions. These are the largest 30, by weight.

| # | Ticker | Name | Weight |
| --- | --- | --- | --- |
| 1 | MRNA | Moderna Inc | 2.44% |
| 2 | TWST | Twist Bioscience Corp | 1.87% |
| 3 | NTRA | Natera Inc | 1.79% |
| 4 | IOVA | Iovance Biotherapeutics Inc | 1.64% |
| 5 | ABBV | AbbVie Inc | 1.62% |
| 6 | UTHR | United Therapeutics Corp | 1.60% |
| 7 | BIIB | Biogen Inc | 1.58% |
| 8 | AMGN | Amgen Inc | 1.56% |
| 9 | GILD | Gilead Sciences Inc | 1.53% |
| 10 | HALO | Halozyme Therapeutics Inc | 1.51% |
| 11 | EXEL | Exelixis Inc | 1.51% |
| 12 | TGTX | Tg Therapeutics Inc | 1.49% |
| 13 | PTGX | Protagonist Therapeutics Inc | 1.45% |
| 14 | SYRE | Spyre Therapeutics Inc | 1.45% |
| 15 | CRSP | Crispr Therapeutics AG | 1.45% |
| 16 | VRTX | Vertex Pharmaceuticals Inc | 1.44% |
| 17 | PCVX | Vaxcyte Inc | 1.42% |
| 18 | PTCT | Ptc Therapeutics Inc | 1.41% |
| 19 | KRYS | Krystal Biotech Inc | 1.40% |
| 20 | GRAL | Grail Inc | 1.37% |
| 21 | REGN | Regeneron Pharmaceuticals | 1.36% |
| 22 | NBIX | Neurocrine Biosciences Inc | 1.35% |
| 23 | RVMD | Revolution Medicines Inc | 1.35% |
| 24 | ERAS | Erasca Inc | 1.34% |
| 25 | ALNY | Alnylam Pharmaceuticals Inc | 1.33% |
| 26 | ORKA | Oruka Therapeutics Inc | 1.32% |
| 27 | INCY | Incyte Corp | 1.32% |
| 28 | ALKS | Alkermes PLC | 1.32% |
| 29 | KOD | Kodiak Sciences Inc | 1.28% |
| 30 | MDGL | Madrigal Pharmaceuticals Inc | 1.27% |

Source: etf.net, https://etf.net/etf/XBI. Please cite the page URL.