---
ticker: "XPH"
name: "State Street SPDR S&P Pharmaceuticals ETF"
url: "https://etf.net/etf/XPH"
grade: "B"
score: 67
graded_at: "2026-10-12"
category: "Pharma & Therapeutics"
category_rank: "2 of 9"
methodology: "https://etf.net/methodology"
---

# XPH: State Street SPDR S&P Pharmaceuticals ETF

Grade **B**, Score 67 of 100. Rank 2 of 9 in Pharma & Therapeutics.

Graded Oct 12, 2026.

## Grade pillars

| Pillar | Score | Category rank |
| --- | --- | --- |
| Cost | 79 | 2 of 9 |
| Mission | 62 | 6 of 6 |
| Risk | 42 | 6 of 9 |
| Tradability | 61 | 5 of 9 |
| Holdings | 89 | 1 of 9 |
| Durability | 69 | 4 of 9 |

## Top holdings

The fund holds 64 positions. These are the largest 30, by weight.

| # | Ticker | Name | Weight |
| --- | --- | --- | --- |
| 1 | XERS | Xeris Biopharma Holdings Inc | 2.72% |
| 2 | MANE | Veradermics Inc | 2.63% |
| 3 | PCRX | Pacira Biosciences Inc | 2.53% |
| 4 | AMRX | Amneal Pharmaceuticals Inc | 2.31% |
| 5 | VTRS | Viatris Inc | 2.14% |
| 6 | PRGO | Perrigo Co PLC | 2.10% |
| 7 | LLY | Eli Lilly & Co | 2.09% |
| 8 | CORT | Corcept Therapeutics Inc | 2.09% |
| 9 | LGND | Ligand Pharmaceuticals | 2.09% |
| 10 | ANIP | Ani Pharmaceuticals Inc | 2.09% |
| 11 | INDV | Indivior Pharmaceuticals Inc | 2.06% |
| 12 | OMER | Omeros Corp | 2.04% |
| 13 | ZTS | Zoetis Inc | 2.04% |
| 14 | PFE | Pfizer Inc | 2.04% |
| 15 | SUPN | Supernus Pharmaceuticals Inc | 2.03% |
| 16 | OGN | Organon & Co | 2.02% |
| 17 | INVA | Innoviva Inc | 2.01% |
| 18 | PBH | Prestige Consumer Healthcare | 1.98% |
| 19 | MRK | Merck & Co. Inc. | 1.97% |
| 20 | MAZE | Maze Therapeutics Inc | 1.96% |
| 21 | JNJ | Johnson & Johnson | 1.96% |
| 22 | ELAN | Elanco Animal Health Inc | 1.95% |
| 23 | DFTX | Definium Therapeutics Inc | 1.94% |
| 24 | HRMY | Harmony Biosciences Holdings | 1.93% |
| 25 | SEPN | Septerna Inc | 1.89% |
| 26 | RPRX | Royalty Pharma PLC Class A | 1.88% |
| 27 | ETON | Eton Pharmaceuticals Inc | 1.88% |
| 28 | COLL | Collegium Pharmaceutical Inc | 1.85% |
| 29 | BMY | Bristol Myers Squibb Co | 1.83% |
| 30 | JAZZ | Jazz Pharmaceuticals PLC | 1.81% |

Source: etf.net, https://etf.net/etf/XPH. Please cite the page URL.