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IBRN

GradeCNew York Stock Exchange Arca

iShares Neuroscience and Healthcare ETF

Themes · IShares · Inception 2022-08-23

$33.88−1.85 (−5.19%)

As of Sep 23, 2026, 1:21 PM EDT

History starts Aug 26, 2022.
Intraday session: down, 10 prints from 35.73 to 33.88. Range 33.88 to 35.67. Use the arrow keys to read each point.$34.50$35.00$35.5010 AM12 PM2 PM4 PM
Expense ratio
0.47%
Fund size
$7M
1Y return
+37.6%
Yield · Last 12 months
0.90%
Holdings
68
Volume · 30D
0M sh
NAV per share
$35.32
52W range
low $25.57high $43.01

The ETF.net IBRN Grade

C

45/ 100

Rank 10 of 17 in Biotech & Genomics

Confidence Medium

Six-pillar profile for IBRN. Scores out of 100: Cost 56, Risk 32, Mission not scored, Tradability 28, Holdings 66, Durability 31. Strongest: Holdings (66). Weakest: Tradability (28). Based on 5 of 6 pillars.
F< 25
D≥ 25
C≥ 40
B≥ 55
A≥ 70

Score 45 of 100 sits in the C band. Bands: A ≥ 70, B ≥ 55, C ≥ 40, D ≥ 25, F < 25; the scale skips E.

  • Cost

    What you pay to own it — the expense ratio plus trading frictions, ranked within its category.
    BScore 56
    Category rank7/17 · top 41%
  • Mission

    How faithfully it does the job it claims — tracking its mandate or index with minimal slippage.
    Not scored
  • Risk

    How violently it can move — volatility, drawdown depth, and downside capture versus its category.
    DScore 32
    Category rank14/17 · bottom quartile
  • Tradability

    How cheaply and easily you can get in and out — liquidity, spread, and premium/discount stability.
    DScore 28
    Category rank14/17 · bottom quartile
  • Holdings

    What it actually owns — the quality, breadth, and concentration of the underlying portfolio.
    BScore 66
    Category rank7/17 · top 41%
  • Durability

    Whether it will still be here — the fund’s assets, age, flows, and issuer staying power.
    DScore 31
    Category rank15/17 · bottom quartile

Graded as of Sep 22, 2026 · Based on 5 of 6 pillars

Our read on IBRN

ETF.net Research

CA healthcare fund with one obsession: the brain. IBRN tracks a global index of roughly 70 drugmakers and device companies working on neurological disease, a slice most sector funds bury inside hundreds of names.

Stated mandate

The fund seeks to track an index of global companies advancing research and treatment of neurological disorders, providing focused exposure to healthcare innovation related to brain health.

Why people hold it

  1. 01A rare single-theme cut of healthcare: brain-disease biopharma and medical devices held together, sourced globally rather than US-only.ishares.com
  2. 02At 0.47%, it undercuts the median expense ratio of its broad healthcare peer group, unusual for a narrow theme fund.
  3. 03Rules-based, not a stock picker: it follows a published NYSE FactSet neuro index, so the exposure you own is defined in advance.ishares.com

Worth knowing

  1. 01Small asset base and thin trading. Spreads can run wider than on the sector's heavyweights, and that cost lands on the buyer.
  2. 020.47% is several times what plain broad healthcare index funds like VHT and XLV charge. The theme is what you're paying for.
  3. 03Roughly 70 names in one research niche, live since 2022. Trial results at a few companies can swing it more than a whole-sector fund.

IBRN Holdings

As of Sep 22, 2026, 4:49 AM
Asset class
Stocks
Holdings
68
Top-10 weight
42%
Largest holding
EWTX4.6%

Sectors

  • Health Care100.0%

Geography

  • United States72.37%
  • Ireland4.82%
  • Netherlands4.50%
  • Canada4.47%
  • South Korea2.52%
  • Sweden2.29%
  • Denmark1.88%
  • Australia1.71%
  • Other countries (6)5.43%

Developed 85% · Emerging 15% of the foreign sleeve

The fund’s holdings, weight-ordered — page 1 of 5.
#TickerCompanyWeight %SharesMarket valueIn ETFs
001EWTXEDGEWISE THERAPEUTICS4.64%7,207$327K67
002USD CASH4.42%311,139$311K193
003BIIBBIOGEN4.31%1,408$303K331
004ACADACADIA PHARMACEUTICALS4.29%11,082$302K128
005ARGXARGENX SE ADR4.23%301$298K68
006PTCTPTC THERAPEUTICS4.16%4,484$293K136
007ALKSALKERMES4.15%6,735$292K151
008NBIXNEUROCRINE BIOSCIENCES4.14%1,997$292K252
009DNTHDIANTHUS THERAPEUTICS INC3.94%2,871$278K81
010PRAXPRAXIS PRECISION MEDICINES3.74%882$264K103
011SRRKSCHOLAR ROCK HOLDING3.71%5,609$262K77
012AXGNAXOGEN3.23%5,141$227K79
013SUPNSUPERNUS PHARMACEUTICALS3.18%5,335$224K127
014DYNDYNE THERAPEUTICS3.10%12,779$219K84
015326030.KSSK BIOPHARMACEUTICALS LTD3.07%3,849$216K41

Showing 1–15 of 73 holdings

IBRN Performance

Shows how $10,000 changes over the selected period, with cash distributions reinvested at the closing price on each ex-dividend date.

IBRN$13,762
SPY tracks large US stocks. It provides market context, rather than representing this fund’s strategy, asset class or investment benchmark.$11,723
Sep 22, 2025 to Sep 22, 2026. IBRN $13,762. SPY $11,723. Use the arrow keys to read each point.$9,039$12,608$16,176Sep 2025Mar 2026Sep 2026

Sep 22, 2025 – Sep 22, 2026

Returns run to the Sep 22, 2026 close, with cash distributions reinvested. Each period starts on the same date that many months or years earlier. Periods over one year show the average yearly return.

Trailing total return for IBRN. Periods over one year show the average yearly return.
PeriodIBRN
Year to date+10.4%
1 month−10.0%
3 months−2.7%
1 year+37.6%
3 years+19.9%per year
5 yearsFund is under 5 years oldper year
10 yearsFund is under 10 years oldper year

As of the close, with distributions reinvested.

Calendar-year total return with cash distributions hypothetically reinvested at the ex-dividend date’s closing price. The current year shows year to date.

Annual total returns for IBRN
YearReturn barIBRN
2026 YTD+10.4%
2025+28.5%
2024−2.8%
2023+0.9%
2022+5.8%

History from Aug 26, 2022

IBRN in the news

ETF.net Research hasn’t filed on IBRN yet — coverage lands here as it’s written.

IBRN Dividends

Adds up every distribution paid per share over the last 12 months, divided by the last completed close. Distributions are counted by ex-date. Data through Sep 22, 2026.
0.90%Last 12 months
Payout per share
$0.32Last 12 months
Last payment
$0.32 per share
Paid on
Shares bought on or after this date do not qualify for this distribution.
Frequency
Annual

Distribution history

2023–2026

One bar per payment. 4 payments from 2023 to 2026 YTD. Jun 7, 2023 $0.0082; Dec 20, 2023 $0.0063; Dec 17, 2024 $0.10; Dec 16, 2025 $0.32. Use the arrow keys to read each point.2023202420252026YTD
Ex-datePay dateAmount per share
Dec 16, 2025Dec 19, 2025$0.32
Dec 17, 2024Dec 20, 2024$0.10
Dec 20, 2023Dec 27, 2023$0.0063
Jun 7, 2023Jun 13, 2023$0.0082

IBRN Risk

How much the fund’s monthly returns vary, scaled to a year.
23.2%
Annualised · 36 months to Aug 2026
How it’s calculated: standard deviation

The sample standard deviation of monthly total returns, multiplied by the square root of 12.

Uses up to 36 complete months, with at least 12 required. Total returns include reinvested distributions.

Return above 3-month US Treasury bills per unit of volatility.
0.69
vs 3-month T-bills · to Aug 2026
How it’s calculated: Sharpe ratio

Subtract each month’s Treasury-bill return from the fund’s monthly total return.

Divide the average of those excess returns by their sample standard deviation, then multiply by the square root of 12.

Uses up to 36 complete months, with at least 12 required. Each month uses the Treasury yield quoted at the end of the previous month.

The largest fall from a peak to the low that followed.
−35.4%
48 months · trough Apr 2025
How it’s calculated: maximum drawdown

The largest percentage decline from an earlier peak, using total returns with reinvested distributions.

Uses up to five years through the last close, with at least 12 months required.

How strongly the fund’s returns move with its asset-class index.
0.87
vs its asset-class index
How it’s calculated: beta

The beta figure is supplied by FMP. The comparison index depends on the fund’s broad asset class.

IBRN Cost

Expense ratio0.47%
  • The middle half of Biotech & Genomics funds
  • Median 0.47%

6 of the 15 Biotech & Genomics funds charge less.

IBRN costs $47.00 a year on $10,000. The median Biotech & Genomics fund costs $47.00.